Proteimer

HOME     PROTEIMER     DEVELOPMENT PROCESS     AFFINITY ENHANCEMENT     MODULAR DESIGN     FAQ

PROTEIMER  
High-Affinity Protein Aptamer Development 

Redefine your therapeutic and diagnostic paradigms with our modular, customizable PROTEIMER platform. We deliver precise discovery, optimization, and validation of high-affinity protein aptamers engineered for your unique biological targets.



Request Consultation


HOME     PROTEIMER     DEVELOPMENT PROCESS     AFFINITY ENHANCEMENT    MODULAR DESIGN     FAQ

PROTEIMER

Novel Aptamer Design
Tailored Target Elucidation
PROTEIMER: A proprietary platform for next-generation protein aptamers, uniting high-efficiency biopanning with an AI-powered design stack (AlphaFold, ProteinMPNN, RFdiffusion) to deliver high-affinity, highly developable binders at speed.
From intractable membrane proteins to enigmatic intracellular targets, we elucidate and rigorously validate potent, high-affinity aptamer ligands, employing sophisticated high-throughput phenotypic screening and advanced biomolecular selection paradigms.
Our novel proprietary platform enables effective targeting of complex biological systems that are often challenging for conventional approaches. 
Our rigorous discovery pipeline seamlessly integrates pioneering phage display, cDNA display, and AI-augmented protein engineering to ensure the rapid identification of premier lead candidates possessing unparalleled binding specificities and therapeutic potential.
Our 

HOME     PROTEIMER     DEVELOPMENT PROCESS     AFFINITY ENHANCEMENT     MODULAR DESIGN    FAQ
  
Development Process


Strategic Target Elucidation
Collaborate closely with our expert scientific team to clearly define your target's key characteristics, application requirements, and pave the way to your project's success.
Custom-Designed Libraries for Targeted Discovery
Our libraries are tailored towards your target class, integrating extensive diversity with rational design to drive the discovery of superior binders.
Iterative Affinity Optimization and Enrichment
Leverage iterative screening cycles with defined selective pressure to isolate and enrich high-affinity binders with strong specificity from complex biological libraries.
Biophysical Characterization 
& Functional Validation
Gain confidence through comprehensive biophysical characterization, including precise affinity quantification, detailed specificity profiling, and functional evaluation in relevant biological models, enhanced by AI-driven design to maximize candidate performance.
HOME     PROTEIMER     DEVELOPMENT PROCESS     AFFINITY ENHANCEMENT     MODULAR DESIGN     FAQ

Affinity Enhancement

Elevating Binding Efficacy Through Directed Evolutionary Pathways
We enhance your aptamer's performance through advanced affinity maturation strategies including directed evolution, error-prone PCR, and structure-guided mutagenesis. This integrated approach drives improved binding specificity, increased physicochemical stability, and mitigates unwanted off-targeted interactions.
Each optimization cycle is supported by computational modeling and rigorous biophysical characterization to validate performance gains. This iterative process enables the development of high-quality aptamers capable of meeting demanding therapeutic and diagnostic benchmarks, including dissociation constants (KD) in the picomolar range.
AI-Driven Protein Engineering
Our distinctive approach leverages advanced artificial intelligence to design and engineer proteins at both the sequence and structural level to enhance their inherent specificity, improve stability under physiological conditions, and maximize their functional performance across diverse biological applications.

Our approach integrates state-of-the-art AI platforms, including AlphaFold, RoseTTAFold, ProteinMPNN, BindCraft, RFantibody and RFdiffusion2. These tools enable accurate structural prediction and the de novo generation of novel tailored protein designs with exceptional precision.
HOME     PROTEIMER     DEVELOPMENT PROCESS     AFFINITY ENHANCEMENT      MODULAR DESIGN    FAQ

Modular Design

Fc Fusions
Enhance pharmacokinetic longevity and confer antibody-dependent cellular cytotoxicity (ADCC) to strengthen therapeutic performance in oncology and advanced immunotherapy settings.
RNase Domains
Enable targeted RNA degradation for precise control of pathogenic and non-coding RNA transcripts.
Cell-Penetrating Peptides
Unlock intracellular delivery to reach challenging cytoplasmic and nuclear targets, expanding therapeutic possibilities beyond cell surface engagement.
BBB-Penetrant Tags
Facilitate transport across the blood-brain barrier using validated targeting strategies. enabling access to CNS targets for neurological applications.

HOME     PROTEIMER     DEVELOPMENT PROCESS     AFFINITY ENHANCEMENT    MODULAR DESIGN     FAQ

FAQ

Which Molecular Targets Can be precisely Engaged by PROTEIMER?

PROTEIMERs are designed to engage diverse target classes, including RNA, peptides, membrane-bound and intracellular proteins, as well as post-translational modifications. The platform supports precise targeting in both extracellular and intracellular environments across multiple therapeutic applications.
What is the Timeline for Project Execution?

Project duration typically spans 8-16 weeks contingent upon the intrinsic complexity of the molecular target, the rigorous stringency of selection protocols, and the exacting validation criteria. However, expedited workflows can be implemented for time-sensitive programs.
What  Project  Deliverables Are Provided?

Clients receive a complete data package during the entire PROTEIMER development cycle. This will include sequence information, binding kinetics analyses (SPR/BLI), validate functional data, and optimized expression and purification protocols. We are also happy to extend strategic guidance for downstream development and intellectual property planning.
Do You Operate Under Stringent Confidentiality Protocols?

We prioritize confidentiality at every stage, supported by standard CDAs and MTAs. All projects are managed with the highest level of discretion, with intellectual property ownership and project terms clearly defined upfront to ensure transparency and security.